Pharmaceutical Intermediate
What is the application of HOPO (Cas No.13161-30-3) Dec 08 , 2021

HOPO(2-Pyridinol-1-oxide) can be used as an additive during peptide synthesis to reduce racemization and thereby increase chiral purity of the final product. Its solubility in water makes it especially useful during solution-phase peptide synthesis. HOPO has also shown to be useful in other applications, including the functionalization of self-assembled monolayers.

CAS: 13161-30-3

Synonym: 2-Hydroxypyridine-N-oxide




  • HOPO is mainly used in amide bond formation in peptide synthesis.
  • HOPO can also be used to remove iron ions by chelation from human transferrin.
  • The ability of self-assembled monolayers on mesoporous silica supports functionalized with HOPO to remove lanthanides.
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